| T2209 |
Serotonin hydrochloride
|
5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride |
5-HT Receptor
,
Endogenous Metabolite
,
Transferase
|
|
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). |
| TN1969 |
N-(p-Coumaroyl) serotonin
|
|
PDGFR
|
|
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving... |
| TN2437 |
Serotonin
|
5-hydroxytryptamine,5-HT |
Others
,
5-HT Receptor
,
Endogenous Metabolite
,
Transferase
|
|
Serotonin (5-hydroxytryptamine) is a natural product from animals |
| T2815 |
Puerarin
|
Kakonein |
5-HT Receptor
|
|
Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist. |
| T9113 |
Myristicin
|
Myristicine |
IL Receptor
,
Anti-infection
,
BCL
,
P450
,
PARP
,
5-HT Receptor
,
Caspase
,
GABA Receptor
,
NO Synthase
|
|
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ... |
| T0525 |
Flopropione
|
Phloropropiophenone |
5-HT Receptor
,
Transferase
|
|
Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist. |
| T19931 |
Gentisein
|
NSC 329491,NSC329491,NSC-329491 |
Serotonin Transporter
|
|
Gentisein (NSC-329491), a primary metabolite of Mangiferin, exhibits significant inhibition of serotonin uptake, demonstrating potency with an IC50 value of 4.7 µM[1][2]. |
| TN1217 |
2'-O-Methylisoliquiritigenin
|
|
Dopamine Receptor
,
5-HT Receptor
,
GABA Receptor
|
|
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ... |
| T6S0654 |
Isocorynoxeine
|
7-Isocorynoxeine |
5-HT Receptor
|
|
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... |
| TN1465 |
Cannabigerol
|
|
NOS
,
5-HT Receptor
,
ROS
|
|
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... |
| TN1032 |
Geissoschizine methyl ether
|
|
5-HT Receptor
|
|
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and ca... |
| T6648 |
Rotundine
|
Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine |
Dopamine Receptor
,
5-HT Receptor
|
|
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
| T0076 |
Paliperidone
|
9-hydroxyrisperidone |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older... |
| T4S1637 |
Gamma-Mangostin
|
Normangostin |
Others
,
5-HT Receptor
|
|
1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ... |
| T3369 |
Nuciferine
|
(-)-Nuciferine,VLT 049,Sanjoinine E |
Dopamine Receptor
,
5-HT Receptor
|
|
Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. |
| T1711 |
Harmine
|
Telepathine |
MAO
,
5-HT Receptor
,
DYRK
|
|
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. |
| TN2865 |
(E)-3,4,5-Trimethoxycinnamic acid
|
O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid |
Others
|
|
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum. |
| T1045 |
Trimipramine maleate
|
Surmontil maleate |
Dopamine Receptor
,
5-HT Receptor
,
Antibacterial
,
Adrenergic Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal... |
| T2811 |
Harmine hydrochloride
|
telepathine hydrochloride |
5-HT Receptor
,
DYRK
,
GluR
|
|
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. |
| T3933 |
Jatrorrhizine
|
Yatrorizine,neprotin |
MAO
,
5-HT Receptor
,
Antibacterial
,
AChE
|
|
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... |
| T1156 |
Palonosetron hydrochloride
|
RS 25259 197,Palonosetron HCl,RS 25259 |
5-HT Receptor
|
|
Palonosetron hydrochloride (RS 25259) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. |
| T4S1659 |
Xanthotoxol
|
8-Hydroxypsoralen,8-Hydroxyfuranocoumarin,Psoralen,8-Hydroxypsoralene |
Reactive Oxygen Species
,
5-HT Receptor
,
Endogenous Metabolite
|
|
Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. |
| T4912 |
Jatrorrhizine chloride
|
Yatrorhizine chloride,Neprotine chloride |
Others
,
5-HT Receptor
,
OCT
,
Antibacterial
,
AChE
|
|
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... |
| T1354 |
N-Acetyl-5-hydroxytryptamine
|
Normelatonin,O-Demethylmelatonin,N-Acetylserotonin |
Trk receptor
,
Endogenous Metabolite
|
|
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to m... |
| T4429 |
Rauwolscine hydrochloride
|
Corynanthidine hydrochloride,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride |
Adrenergic Receptor
|
|
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) , a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes b... |
| T6S1684 |
8-Gingerol
|
|
Antioxidant
,
Antibacterial
,
TRP/TRPV Channel
|
|
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... |
